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3 posts from November 2011

November 30, 2011

Green Detox Q & A - What is Chlorella?

BlogGDQAC Q. Green Detox contains Chlorella. What is Chlorella?

A. Chlorella is a nutrient–dense, single–celled green algae which gets its name from its notably high chlorophyll content. In addition to being nature's richest source of chlorophyll, chlorella also contains vitamins, minerals, amino acids, nucleic acids, enzymes, chlorella growth factor (CGF), and unique types of dietary fiber.

Microalgae such as chlorella are among the most primitive species on our planet, and Chlorella represents the first "plant" with a distinct cell nucleus. Chlorella is known to reproduce with particular rapidity and efficiency – a single chlorella cell can divide into four cells every 16 to 20 hours, and it was once predicted that chlorella could yield more protein per unit area than any other plant on earth.

In the 1940s, numerous scientists warned that rapid worldwide population growth would soon place a serious strain on the world's food supply. Its rapid growth rate and unparalleled nutrient density made chlorella a promising candidate in the fight against world hunger. By the 1950s and 60s, Chlorella was also being investigated as a both a nutrient and oxygen source to be used in space travel.

Ultimately, however, improvements in land–based agricultural practices made chlorella relatively unsuited for production on the scale needed to feed the world. But, though Chlorella may not be an economically–viable means to end world hunger, it still offers the health–conscious consumer an incredibly concentrated source of complete nutrition – with unique benefits for the immune and detoxicative systems.*

In vitro, animal, and human studies have shown that Chlorella may be able to enhance immune function*:

Study Link – Immunostimulatory Bioactivity of Algal Polysaccharides from Chlorella pyrenoidosa Activates Macrophages via Toll–Like Receptor 4.

Study Link – Immunomodulation by a unicellular green algae (Chlorella pyrenoidosa) in tumor–bearing mice.

Quote from the above study:

Since Chlorella cells and derivatives showed no indication of direct in vitro cytotoxicity to either tumor or mouse spleen cells, the antitumor effects documented may be mediated by host immune response.

Study Link – Dietary Chlorella pyrenoidosa for patients with malignant glioma: Effects on immunocompetence, quality of life, and survival.

Studies have also shown evidence that Chlorella may support healthy blood flow, blood lipids, and gastrointestinal function*:

Study Link – Nutritional supplementation with Chlorella pyrenoidosa for mild to moderate hypertension.

Study Link – Preventing dyslipidemia by Chlorella pyrenoidosa in rats and hamsters after chronic high fat diet treatment.

Study Link – Effect of chlorella and its fractions on blood pressure, cerebral stroke lesions, and life–span in stroke–prone spontaneously hypertensive rats.

Study Link – A review of recent clinical trials of the nutritional supplement Chlorella pyrenoidosa in the treatment of fibromyalgia, hypertension, and ulcerative colitis.

But, perhaps more than any other food, chlorella has repeatedly been studied for its powerful ability to help aid the body in the detoxification and elimination of numerous harmful chemicals, including dioxins, pesticides, and heavy metals:

Study Link – Effect of Chlorella pyrenoidosa on fecal excretion and liver accumulation of polychlorinated dibenzo–p–dioxin in mice.

Study Link – Detoxification of chlordecone poisoned rats with chlorella and chlorella derived sporopollenin.

Study Link – Chlorophyll derived from Chlorella inhibits dioxin absorption from the gastrointestinal tract and accelerates dioxin excretion in rats.

Study Link – Effect of Chlorella intake on Cadmium metabolism in rats.

Study Link – Protective effects of Chlorella vulgaris in lead–exposed mice infected with Listeria monocytogenes.

Chlorella has even been shown to reduce the transfer of dioxins from the mother to the infant, both via placental transfer, and via breast milk after birth:

Study Link – Maternal–fetal distribution and transfer of dioxins in pregnant women in Japan, and attempts to reduce maternal transfer with Chlorella (Chlorella pyrenoidosa) supplements.

Green DetoxJPGQuote from the above study:

Total TEQ [toxic equivalents] in cord blood were approximately 26% lower than in maternal blood (P<0.0001). The results of this study suggest that transplacental transfer differs depending on the dioxin congener. Total TEQ in breast milk were approximately 30% lower in the Chlorella group than in controls (P=0.0113). This finding suggests that maternal transfer of dioxins can be reduced using dietary measures such as Chlorella supplements.

These unique detoxifying effects are likely unsurpassed by any land–based vegetable. As such, even those of us who eat plenty of "greens" can still benefit from the unique benefits of chlorella.

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Related Posts:

What is Green Detox?

What is Fucoidan?

 

 

November 28, 2011

Green Detox Q & A - What is Fucoidan?

BlogGDQACQ. Green Detox contains Maritech® Synergy - a concentrated extract of fucoidan. What, exactly, is fucoidan?

A. Fucoidan is a collective term for various sulfated polysaccharides (chains of sugar molecules) derived from species of brown seaweed such as Fucus vesiculosus (aka bladderwrack) and Undaria pinnatifida (aka wakame). The unique polysaccharide structure of fucoidans allows them to modulate cellular communication. For example, fucoidans have been shown to be powerful immunomodulators – substances which improve the efficiency of the body's immune response. An immune system which performs its duties efficiently is able to rid the body of diseased and damaged cells, and build healthy cells – all without the "collateral damage" caused by excessive inflammation.

As a frame of reference, many substances which supposedly "reduce inflammation" do so by impairing the activity of immune cells. This is true, for example, of the anti–inflammatory drug, cortisone and even supplemental doses of omega–3 fish oils. While such substances often offer symptomatic improvement for inflammatory conditions, they may also compromise the important pathogen–fighting and tissue building functions of the immune system.

Fucoidan, on the other hand, seems to reduce certain harmful aspects of inflammation, while, at the same time, supporting the tissue–building and pathogen–fighting aspects of immune function.

The following study, for example, found that a fucoidan–containing mixture of seaweed and minerals elicited a significant increase in the production of cytotoxic T cells and a near–significant increase in natural killer cells (NK cells). At the same time, the mixture also elicited a decrease in the inflammatory marker, Interleukin–6 (IL–6):

Study Link – A combined Phase I and II open–label study on the immunomodulatory effects of seaweed extract nutrient complex.

Quote from the above study:

In addition to immune modulation, the complex has potential anti–inflammatory activity, exhibited by the significant decrease in IL–6 between day 1 and day 28.

In another preliminary study, a fucoidan–containing seaweed mixture was found to reduce osteoarthritis symptoms and joint pain.* In those taking the fucoidan–containing mixture, the Comprehensive Osteoarthritis Test (COAT) – an established method for measuring arthritis symptoms – showed up to a 50.7% reduction in symptoms over the course of the study:

Study Link – A combined phase I and II open label study on the effects of a seaweed extract nutrient complex on osteoarthritis.

Evidence also suggests a possible protective effect of fucoidan against numerous viruses:

Study Link – Defensive effects of a fucoidan from brown alga Undaria pinnatifida against herpes simplex virus infection.

Where they are found only in brown seaweeds, fucoidans are consumed significantly in East Asian countries (Japan, China, Korea) where such foods represent staples of the diet. The consumption of brown seaweeds (and thus, fucoidan) is negligible, however, in almost every other culture across the globe. It has thus been proposed that fucoidans may be a unique contributor to the health and longevity often noted in coastal regions of East Asia.

Asian cultures are known for their relatively low incidence of metabolic syndrome – a cluster of symptoms which include obesity, high blood pressure, elevated blood lipids, and blood sugar disorders. While metabolic syndrome may affect up to 20% of the population of certain Western societies (such as the U.S.), incidence in Japan is among the lowest in the world at approximately 7%. This low incidence of metabolic syndrome is thought to be a major contributing factor to Japan's world–leading life expectancy.

Seaweeds contain numerous substances which may inhibit the development of the metabolic syndrome, and fucoidan from brown seaweed may be among the most powerful. Studies have found that the consumption of brown seaweed (Undaria pinnatifida) was associated with reduced waist circumference in women, and well as imparting a normalizing effect on systolic blood pressure:

Study Link – Could dietary seaweed reverse the metabolic syndrome?

In vitro studies have found that fucoidan is able to stimulate lipolysis (the breaking down of fats) which researchers speculate may ultimately be important in preventing obesity:

Study Link – Fucoidan from marine brown algae inhibits lipid accumulation.

Quote from the above study:

Since increase of HSL and p–HSL expression and decrease of glucose uptake into adipocytes are known to lead to stimulation of lipolysis, our results suggest that fucoidan reduces lipid accumulation by stimulating lipolysis. Therefore, these results suggest that fucoidan can be useful for the prevention or treatment of obesity due to its stimulatory lipolysis.

Metabolic syndrome and diabetes are characterized by high levels of advanced glycation endproducts (AGEs) – reactive substances formed from the interaction of proteins and sugars. AGEs can be consumed in food, but are particularly apt to be formed endogenously in diabetics due to chronically–elevated blood sugar levels. The presence of elevated AGEs is known to have particularly negative consequences for blood vessels and circulation. When AGEs attach to cellular receptors, the result can be a chronic inflammatory state associated with numerous age–related disorders including cardiovascular disease, and it's currently thought that AGEs may be largely responsible for the vascular disorders associated with diabetes.

One of the most far–reaching anti–aging benefits of fucoidan may involve the polysaccharide's ability to prevent the adherence of AGEs to AGE receptors (RAGE):

Study Link – FEEL–1 and FEEL–2 Are Endocytic Receptors for Advanced Glycation End Products.

Quote from the above study:

The 125 I–AGE–BSA binding to CHO–FEEL–1 and CHO–FEEL–2 cells was effectively inhibited by Ac–LDL and polyanionic SR–A inhibitors such as fucoidan, polyinosinic acids, and dextran sulfate but not by native LDL, oxidized LDL, or HDL.

Similarly, fucoidan's ability to inhibit leukocyte adherence within blood vessels has been shown to restore normal capillary blood flow in diabetic animals.

Study Link – Inhibition of leukocyte adherence enables venular control of capillary perfusion in streptozotocin–induced diabetic rats.

Advanced glycation end products have also been implicated in, perhaps, the most visible sign of aging – skin wrinkling:

Study Link – The Role of Hyperglycemia in Skin Wrinkle Formation: Mediation of Advanced Glycation End–Products.

Fucoidan's ability to inhibit the effects of AGEs may be a significant reason why fucoidan supports healthy, youthful skin. Studies have found fucoidan possesses the ability to inhibit several enzymes which are involved in skin aging, including elastase in the following study:

Study Link – Fucoidan a sulfated polysaccharide from brown algae is a potent modulator of connective tissue proteolysis.

Quote from the above study:

Using tissue sections of human skin in ex vivo experiments, we evidenced that this polysaccharide was able to minimize human leukocyte elastase activity resulting in the protection of human skin elastic fiber network against the enzymatic proteolysis due to this serine proteinase.

Even topical applications of brown seaweeds have been found to impart significant anti–aging activity upon skin:

Study Link – Treatment of human skin with an extract of Fucus vesiculosus changes its thickness and mechanical properties.

Quote from the above study:

A significant decrease in skin thickness measured by B–mode ultrasound was elicited, as was a significant improvement in elasticity measured with a Cutometer as compared with controls. In cheek skin, the thickness normally increases and the elasticity usually decreases with age. These results suggest that the Fucus vesiculosus extract possesses anti–aging activities and should be useful for a variety of cosmetics.

Green DetoxJPGFrom this research, it seems likely that many of the health attributes associated with Asian cultures – from low incidence of metabolic syndrome to clear, wrinkle–resistant skin – may have much to do with the unique properties of fucoidan found in brown seaweed. It's important to emphasize the fact that brown seaweeds and fucoidan are almost completely absent from the Western diet. Nori seaweed (commonly used in sushi preparation) is a red seaweed which doesn't contain fucoidan. Other common sea vegetables sold as nutritional supplements (e.g., spirulina and blue–green algae) won't contain fucoidan either. For this reason, Green Detox is formulated with three sources of fucoidan including the standardized fucoidan extract known as Maritech Synergy®.

November 26, 2011

Green Detox Q & A - What is Green Detox?

BlogGDQACOur new product, Green Detox, has arrived! In the coming weeks, we'll present a series of question and answer articles giving an overview of the unique health benefits Green Detox has to offer.

What is Green Detox?

Green Detox is a precise blend of nutrient–rich sea vegetables designed to support healthy metabolism*, immune function*, and the body's natural detoxification mechanisms.

Though modern agricultural practices often deplete important nutrients from the soils, the oceans of the world remain a nearly limitless nutritional resource. This makes sea vegetables among the planet's most concentrated sources of nutrients – they contain an array of vitamins, minerals, dietary fiber, and chlorophyll simply unmatched by any land–based vegetable.

With increasing research on the health–promoting benefits of sea vegetables, it seems to be no coincidence that cultures which consume sea vegetables (i.e., seaweed) are often known for their robust health and longevity (the Okinawans of Japan being, perhaps, the quintessential example). But sea vegetables are very rarely consumed in the United States and the rest of the industrialized Western world. This is why we at Integrated Supplements are proud to introduce Green Detox Sea Vegetable Blend – a nutrient–rich blend of the most health–promoting sea vegetables sourced from pristine waters around the globe, untouched by human or industrial pollution.

Green Detox is far more than just a concentrated source of nutrients. The sea vegetables in Green Detox may also be able to help rid the body of some of the industrialized world's most harmful chemicals.* Certain sea vegetables may possess the unique ability to help rid the body of toxins such as heavy metals, radioactive elements, organochlorine pesticides, PCBs, and dioxin.* These same sea vegetables have also been shown to aid the clearing of fatty wastes from the liver*, and to support the growth of beneficial bacteria in the intestines.*

What are the Ingredients in Green Detox?

Green Detox contains numerous sea vegetables (technically, algae) which have been chosen for their unique health effects, including:

SupplementFactsGreens

Organic Maritech® Synergy (85% Fucoidan from Fucus vesiculosus) – Fucoidan is a polysaccharide found in brown seaweed which may help to maintain a healthy immune system and aid in proper cell growth and repair.*

Organic Bladderwrack (Fucus vesiculosus) – In addition to fucoidan, bladderwrack is a source of:

Polysaccharides which may support healthy hormone levels.*

Alginate – A natural absorbent of radioactive elements, heavy metals (i.e., lead mercury), and free radicals.*

Iodine and other nutrients which may support healthy thyroid function and metabolism.*

Green DetoxJPGOrganic Wakame (Undaria pinnatifida) – Wakame is a highly-nutritious sea vegetable and may provide unique benefits for immune function*, and healthy blood flow.* Potent antioxidants in wakame may also support clear and beautiful skin.*

Japanese Cracked-Cell Chlorella – contains vitamins, minerals, chlorophyll, antioxidants, and chlorella growth factor (CGF). Chlorella may support healthy levels of beneficial bacteria in the intestines, and may act as a unique supporter of the body's natural detoxification mechanisms.*

The ingredients in Green Detox have been specifically chosen for their incredible nutrient density, as well as the presence of health-promoting substances which are almost completely absent from the Western diet.

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